检索范围:
排序: 展示方式:
Small-molecule anti-COVID-19 drugs and a focus on China’s homegrown mindeudesivir (VV116)
《医学前沿(英文)》 doi: 10.1007/s11684-023-1037-3
Repurposing clinical drugs is a promising strategy to discover drugs against Zika virus infection
Weibao Song, Hongjuan Zhang, Yu Zhang, Rui Li, Yanxing Han, Yuan Lin, Jiandong Jiang
《医学前沿(英文)》 2021年 第15卷 第3期 页码 404-415 doi: 10.1007/s11684-021-0834-9
关键词: Zika virus clinical drugs ZIKV inhibitors antivirals repurposing
Direct acting antiviral-induced dynamic reduction of serum
Tung Huynh, Ke-Qin Hu
《医学前沿(英文)》 2019年 第13卷 第6期 页码 658-666 doi: 10.1007/s11684-019-0707-7
关键词: chronic hepatitis C α fetoprotein direct acting antiviral treatment cirrhosis
ROUTE DEVELOPMENT, ANTIVIRAL STUDIES, FIELD EVALUATION AND TOXICITY OF AN ANTIVIRAL PLANT PROTECTANT
《农业科学与工程前沿(英文)》 2022年 第9卷 第1期 doi: 10.15302/J-FASE- 2021390
It has previously been shown that tryptophan, the biosynthesis precursor of Peganum harmala alkaloids, and its derivatives have anti-TMV activity both in vitro and in vivo. Further exploration of this led to the identification of NK0238 as a highly effective agent for the prevention and control of diseases caused by plant viruses, but the existing routes are unsuitable for its large-scale synthesis. This study optimized a route for two-step synthesis of this virucide candidate via reaction of l-tryptophan with triphosgene to produce l-tryptophan-N-carboxylic anhydride, which then reacts with n-octylamine to give NK0238 at up to 94% yield and nearly 97% HPLC purity. In addition, the route was used for the preparation of NK0238 on a>40 g scale permitting further assessment of its antivirus activity in the greenhouse and field experiments, and toxicity tests. NK0238 exhibited useful antiviral activities against a variety of viruses both in greenhouse and field experiments. The toxicity tests showed that NK0238 was not acutely toxic to birds, fish, honey bees and silkworms. The optimized route provides a solid foundation for its large-scale synthesis and subsequent efficacy and toxicity studies, its excellent activity and safety make NK0238 a promising drug candidate for further development.
Design, synthesis, and antiviral properties of 2-aryl-1H-benzimidazole-4-carboxamide derivatives
Xianjin LUO, Zhonglü ZHANG, Yutian YANG, Fei XUE, Naiyun XIU, Yuanbin SHE
《化学科学与工程前沿(英文)》 2009年 第3卷 第3期 页码 305-309 doi: 10.1007/s11705-009-0021-z
ROUTE DEVELOPMENT, ANTIVIRAL STUDIES, FIELD EVALUATION AND TOXICITY OF AN ANTIVIRAL PLANT PROTECTANT
Wentao XU, Hao TIAN, Hongjian SONG, Yuxiu LIU, Yongqiang LI, Qingmin WANG
《农业科学与工程前沿(英文)》 页码 110-119 doi: 10.15302/J-FASE-2021390
关键词: antiviral plant protectant antiviral in the greenhouse field evaluation L-trp-NCA synthesis optimization toxicity tests
Peng Hu, Changsheng Guo, Yan Zhang, Jiapei Lv, Yuan Zhang, Jian Xu
《环境科学与工程前沿(英文)》 2019年 第13卷 第4期 doi: 10.1007/s11783-019-1140-5
We developed a method for determining 11 abused drugs in water and sediment. METH and EPH were the dominant drugs in water and sediment in Beiyunhe River. Abuse drugs in Beiyunhe River were mainly from hospitals and sewage effluents. Abused drugs in the water would not impair the aquatic ecosystem biologically.
关键词: Drugs of abuse Occurrence Distribution Urban river Environmental risk
Ying HUANG, Clement Wesley GNANADURAI, Zhenfang FU
《农业科学与工程前沿(英文)》 2017年 第4卷 第3期 页码 260-267 doi: 10.15302/J-FASE-2016116
关键词: antiviral blood brain barrier chemokines and cytokines innate immunity rabies virus
《农业科学与工程前沿(英文)》 2021年 第8卷 第4期 页码 603-622 doi: 10.15302/J-FASE -2021397
The COVID-19 infections caused by SARS-CoV-2 have resulted in millions of people being infected and thousands of deaths globally since November 2019. To date, no unique therapeutic agent has been developed to slow the progression of this pandemic. Despite possessing antiviral traits the potential of bacteriocins to combat SARS-CoV-2 infection has not been fully investigated. This review summarizes the mechanisms by which bacteriocins can be manipulated and implemented as effective virus entry blockers with infection suppression potential properties to highly transmissible viruses through comprehensive immune modulations that are potentially effective against COVID-19. These antimicrobial peptides have been suggested as effective antiviral therapeutics and therapeutic supplements to prevent rapid virus transmission. This review also provides a new insight into the cellular and molecular alterations which have made SARS-CoV-2 self-modified with diversified infection patterns. In addition, the possible applications of antimicrobial peptides through both natural and induced mechanisms in infection prevention perspectives on changeable virulence cases are comprehensively analyzed. Specific attention is given to the antiviral mechanisms of the molecules along with their integrative use with synthetic biology and nanosensor technology for rapid detection. Novel bacteriocin based therapeutics with cutting-edge technologies might be potential substitutes for existing time-consuming and expensive approaches to fight this newly emerged global threat.
Chinese expert consensus on oral drugs for the treatment of mature B-cell lymphomas (2020 edition)
《医学前沿(英文)》 2022年 第16卷 第5期 页码 815-826 doi: 10.1007/s11684-021-0891-0
关键词: B-cell lymphoma oral drug targeted therapy immunotherapy COVID-19 pandemic
Vaibhav Mundra, Ram I. Mahato
《化学科学与工程前沿(英文)》 2014年 第8卷 第4期 页码 387-404 doi: 10.1007/s11705-014-1457-3
关键词: nanocarrier cellular uptake endosomal release nucleic acid drug
Current recommendations of managing HBV infection in preconception or pregnancy
null
《医学前沿(英文)》 2014年 第8卷 第2期 页码 158-165 doi: 10.1007/s11684-014-0340-4
Hepatitis B remains a leading cause of cirrhosis, hepatocellular carcinoma and liver transplantation worldwide. Management of chronic hepatitis B during pregnancy is challenging. Transmission of hepatitis B to infants still occurs perinatally although immunoprophylaxis is widely available for infants born to mothers with chronic hepatitis B infection. The emerging data suggest that initiation of antiviral therapy in the beginning of the third trimester in highly viremic mothers can prevent immunoprophylaxis failure in their infants. The available drug safety data show that lamivudine, telbivudine and tenofovir are generally safe to be used during the pregnancy. In order to minimize the fetal exposure to the antiviral medication, antiviral therapy during the pregnancy should be limited to a selected group of patients with cirrhosis, high hepatitis B viral load, or prior history immunoprophylaxis failure. An elective Caesarean section may reduce the risk of perinatal transmission. For those females planning for pregnancy or in early stage of pregnancy, communication and follow-up among obstetrician, gastroenterologist, and primary care physician are important. In this article, we will review the features of hepatitis B infection before, during and after the pregnancy; the risk factors that increase mother-to-child transmission; safety data on antiviral drug use during pregnancy; and the potential role of Caesarean section in selected cases.
关键词: antiviral therapy Caesarean section cirrhosis hepatitis B immunoprophylaxis mother-to-child transmission pregnancy prevention
Sufen ZHAO,Yuanyuan JIA,Weiwei ZHANG,Lili WANG,Yunfei MA,Kedao TENG
《农业科学与工程前沿(英文)》 2015年 第2卷 第4期 页码 318-326 doi: 10.15302/J-FASE-2015080
关键词: garlic infectious bursal disease virus (IBDV) antiviral effect IgM-bearing B lymphocyte
Telomeric impact of conventional chemotherapy
null
《医学前沿(英文)》 2013年 第7卷 第4期 页码 411-417 doi: 10.1007/s11684-013-0293-z
The increased level of chromosome instability in cancer cells, leading to aneuploidy and gross chromosomal rearrangements, is not only a driving force for oncogenesis but also can be the Achille’s heel of the disease since many chemotherapies (CT) kill cells by inducing a non-tolerable rate of DNA damage. A wealth of published evidence showed that telomere stability can be more affected than the bulk of the genome by several conventional antineoplasic drugs. These results raise the interesting possibility that CT with genotoxic drugs preferentially target telomeres. In agreement with this view, accelerated shortening of telomere length has been described in blood lineage cells following high-dose CT (stem cell transplantation) or non-myeloablative CT. However, almost nothing is known on the consequences of this shortening in terms of telomere stability, senescence and on the development of second cancers or post-treatment aging-like syndromes in cancer survivors (cognitive defect, fertility impairment, etc.). In this article, we propose: (1) telomeres of cancer cells are preferential genomic targets of chemotherapies altering chromosome maintenance; (2) telomere functional parameters can be a surrogate marker of chemotherapy sensitivity and toxicity; (3) the use of anti-telomere molecule could greatly enhance the sensitivity to standards chemotherapies.
关键词: telomere antineoplasic drugs conventional chemotherapies
标题 作者 时间 类型 操作
Repurposing clinical drugs is a promising strategy to discover drugs against Zika virus infection
Weibao Song, Hongjuan Zhang, Yu Zhang, Rui Li, Yanxing Han, Yuan Lin, Jiandong Jiang
期刊论文
ROUTE DEVELOPMENT, ANTIVIRAL STUDIES, FIELD EVALUATION AND TOXICITY OF AN ANTIVIRAL PLANT PROTECTANT
期刊论文
Design, synthesis, and antiviral properties of 2-aryl-1H-benzimidazole-4-carboxamide derivatives
Xianjin LUO, Zhonglü ZHANG, Yutian YANG, Fei XUE, Naiyun XIU, Yuanbin SHE
期刊论文
ROUTE DEVELOPMENT, ANTIVIRAL STUDIES, FIELD EVALUATION AND TOXICITY OF AN ANTIVIRAL PLANT PROTECTANT
Wentao XU, Hao TIAN, Hongjian SONG, Yuxiu LIU, Yongqiang LI, Qingmin WANG
期刊论文
Occurrence, distribution and risk assessment of abused drugs and their metabolites in a typical urban
Peng Hu, Changsheng Guo, Yan Zhang, Jiapei Lv, Yuan Zhang, Jian Xu
期刊论文
Critical roles of chemokines and cytokines in antiviral innate immune responses during rabies virus infection
Ying HUANG, Clement Wesley GNANADURAI, Zhenfang FU
期刊论文
ANTIVIRAL EFFECTS OF BACTERIOCIN AGAINST ANIMAL-TO-HUMAN TRANSMITTABLE MUTATED SARS-COV-2: A SYSTEMATIC
期刊论文
Chinese expert consensus on oral drugs for the treatment of mature B-cell lymphomas (2020 edition)
期刊论文
nanocarriers for efficient cellular uptake and endosomal release of small molecule and nucleic acid drugs
Vaibhav Mundra, Ram I. Mahato
期刊论文